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Evidential Context: Placing Triple Agonism in the Incretin Landscape The metabolic outcome progression across incretin generations from early GLP-1 mono-agonists, through later long-acting GLP-1 mono-agonists, to Phase 3 triple agonist investigational data represents a systematic pharmacological advance, not simply dose escalation

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Successful hydrophobication of GSH-AuNCs and their excellent colloidal stability in organic solvents encouraged us to evaluate their encapsulation into PLGA nanoparticles using a modified nanoprecipitation method and the emulsion-evaporation method, as detailed earlier in the manuscript

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